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  1. Mortality studies and the effectiveness of drugs in long-term treatment.

    Article - En anglais

    In scientific observations on the utilization of drugs under routine treatment conditions in patients with affective disorders, one of the main problems is the etablishment of criteria for measuring treatment effectiveness.

    As the mortality risk of such patients is considerable, the mortality rate is an important outcome criterion for determining the long-term effectiveness of medication administered in routine treatment settings.

    Mortality studies are typical phase IV studies : the researcher does not interact with the treatment procedure, he only observes the results of treatment with respect to death rates.

    As lithium treatment is of increasing importance and interest as a major prophylactic agent in recurrent affective disorders and is by its nature a long-term treatment, such a therapy provides an excellent field for observations of effectiveness under long-term treatment conditions.

    Mortality studies can take into account various factors, such as type of treatment setting, treatment regimen, drop-out analysis, and comparison between times on and off treatment.

    Results from several mortality studies on lithium-treated patients are reported in order to demonstrate the methodology and outcome of long-term observation of drug treatment. (...)

    Mots-clés Pascal : Antidépresseur, Psychotrope, Chimiothérapie, Efficacité traitement, Critère, Mortalité, Méthodologie, Epidémiologie, Homme, Toxicité

    Mots-clés Pascal anglais : Antidepressant agent, Psychotropic, Chemotherapy, Treatment efficiency, Criterion, Mortality, Methodology, Epidemiology, Human, Toxicity

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0120510

    Code Inist : 002B02B02. Création : 21/05/1997.