This study presents a methodological approach to an ex post facto investigation of sample bias in drug utilization observation (DUO) studies using the example of a DUO with the non-tricyclic antidepressant fluoxetine.
A total of 479 psychiatrists and neurologists and 2,401 patients were investigated.
The purpose of the study was to judge the representativeness of our DUO sample for two populations : first, for all psychiatrics and neurologists prescribing fluoxetine or all patients being treated with fluoxetine in Germany and, second, for all psychiatrists and neurologists prescribing antidepressants or all patients being treated with antidepressants in Germany.
Criteria for the representativeness test were physician variables (gender, size of community where practicing, federal state, age, volume of prescriptions) and patient variables (gender, age, prescription-related diagnosis, concurrent illnesses, concomitant medications).
The study shows that the DUO sample can rightfully claim representativeness in the majority of parameters for the psychiatrists and neurologists prescribing fluoxetine and for the patients being treated with fluoxetine.
There are more noticeable discrepancies with regard to the psychiatrists and neurologists in general and to the patients being treated with antidepressants in general.
The methodological problems of pharmacoepidemiological investigation of representativeness are discussed.
Mots-clés Pascal : Prescription médicale, Fluoxétine, Inhibiteur recapture, Sérotonine, Antidépresseur, Psychotrope, Chimiothérapie, Traitement, Méthodologie, Biais méthodologique, Epidémiologie, Homme
Mots-clés Pascal anglais : Medical prescription, Fluoxetine, Reuptake inhibitor, Serotonin, Antidepressant agent, Psychotropic, Chemotherapy, Treatment, Methodology, Methodological bias, Epidemiology, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0120384
Code Inist : 002B02B02. Création : 21/05/1997.