To determine the role of preexisting Helicobacter pylon infection in the development of acute upper gastrointestinal (GI) hemorrhage in intensive care unit (ICU) patients in relation to other potential predisposing risk factors.
Prospective, multicenter, cohort study.
Medical and surgical ICUs in six tertiary care Department of Veterans Affairs Medical Centers.
Eight-hundred seventy-four patients without previous Gl bleeding or peptic ulcer disease who were enrolled in a multicenter, randomized, controlled trial of prophylactic intravenous immunoglobulin to prevent ICU-assoclated infections.
This substudy of the larger intravenous immunoglobulin study only involved data analysis and had no intervention.
All patients were enrolled in the larger study where they received intravenous immunoglobulin or placebo as intervention.
Patients were prospectively evaluated for the development of acute upper GI hemorrhage while in an ICU.
Anti-H. pylori immunoglobulin G and immunoglobulin A concentrations were determined by enzyme immunoassay on preintervention serum samples.
Seventy-six (9%) patients had overt upper GI bleeding and a mortality rate of 49%, as compared with a 15% mortality rate in patients who did not bleed (p<. 001). (...)
Mots-clés Pascal : Hémorragie, Gastrointestinal, Voie aérodigestive supérieure, Unité soin intensif, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Anticorps, Plasma sanguin, Immunoglobuline, Epidémiologie, Facteur risque, Homme, Etude cohorte, Etude multicentrique, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Soin intensif
Mots-clés Pascal anglais : Hemorrhage, Gastrointestinal, Upper aerodigestive tract, Intensive care unit, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Antibody, Blood plasma, Immunoglobulins, Epidemiology, Risk factor, Human, Cohort study, Multicenter study, Digestive diseases, Gastric disease, Intestinal disease, Cardiovascular disease, Vascular disease, Intensive care
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0080616
Code Inist : 002B27B05. Création : 21/05/1997.