We reported high levodopa use and prevalences of Parkinson's Disease (PD) in periodically, time-clustered, Icelandic cohorts born after major whooping cough epidemics (MWCE).
In order to quantify a possible relationship between age at first post-birth MWCE and risk of PD we : 1) calculated cumulative incidences of PD during the period 1954-1963 in one-year Icelandic cohorts born between 1869 and 1927, using raw material from a reported survey ; 2) identified MWCE from 1869 onwards in Iceland ; 3) estimated cohort ages at onset of incidence period and at first MWCE ; and 4) combined the above-mentioned information using log-linear models.
In addition, we studied the prevalence of levodopa users in Icelandic birth cohorts during a recent period.
The curves of the above-mentioned incidences and prevalences in one-year birth-cohorts showed : 1) a similar, age-related, inverted V profile ; and 2) a systematic notchy pattern, with peak values for one or both measurements for cohorts born during or after each of nine MWCE identified during the period 1869-1927.
When 13 cohorts born in years with MWCE were excluded from the analysis, the risk of PD rose with age at first defined MWCE, with the linear increase being 8.4% per year (95% CI : - 0.1-18.3%). Conclusions. (...)
Mots-clés Pascal : Parkinson maladie, Coqueluche, Bactériose, Infection, Facteur risque, Homme, Epidémiologie, Islande, Iles Atlantiques, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Parkinson disease, Whooping cough, Bacteriosis, Infection, Risk factor, Human, Epidemiology, Iceland, Atlantic Ocean Islands, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease, Respiratory disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0080516
Code Inist : 002B17G. Création : 21/05/1997.