Whooping cough and Parkinson's disease.
We reported high levodopa use and prevalences of Parkinson's Disease (PD) in periodically, time-clustered, Icelandic cohorts born after major whooping cough epidemics (MWCE).
In order to quantify a possible relationship between age at first post-birth MWCE and risk of PD we : 1) calculated cumulative incidences of PD during the period 1954-1963 in one-year Icelandic cohorts born between 1869 and 1927, using raw material from a reported survey ; 2) identified MWCE from 1869 onwards in Iceland ; 3) estimated cohort ages at onset of incidence period and at first MWCE ; and 4) combined the above-mentioned information using log-linear models.
In addition, we studied the prevalence of levodopa users in Icelandic birth cohorts during a recent period.
The curves of the above-mentioned incidences and prevalences in one-year birth-cohorts showed : 1) a similar, age-related, inverted V profile ; and 2) a systematic notchy pattern, with peak values for one or both measurements for cohorts born during or after each of nine MWCE identified during the period 1869-1927.
When 13 cohorts born in years with MWCE were excluded from the analysis, the risk of PD rose with age at first defined MWCE, with the linear increase being 8.4% per year (95% CI : - 0.1-18.3%). Conclusions. (...)
Mots-clés Pascal : Parkinson maladie, Coqueluche, Bactériose, Infection, Facteur risque, Homme, Epidémiologie, Islande, Iles Atlantiques, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Parkinson disease, Whooping cough, Bacteriosis, Infection, Risk factor, Human, Epidemiology, Iceland, Atlantic Ocean Islands, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0080516
Code Inist : 002B17G. Création : 21/05/1997.