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  1. The lack of selection bias in a snowball sampled case-control study on drug abuse.

    Article - En anglais

    Background

    Friend controls in matched case-control studies can be a potential source of selection bias based on the assumption that friends are more likely to share exposure factors.

    This study evaluates the role of selection bias in a case-control study that used the snowball sampling method based on friendship for the selection of cases and controls.

    Methods

    The cases selected for the study were drug abusers located in the community.

    Exposure was defined by the presence of at least one psychiatric diagnosis.

    Psychiatric and drug abuse/dependence diagnoses were made according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R) criteria.

    Cases and controls were matched on sex, age and friendship.

    The measurement of selection bias was made through the comparison of the proportion of exposed controls selected by exposed cases (p1) with the proportion of exposed controls selected by unexposed cases (p2).

    If p1=p2, then, selection bias should not occur.

    Results

    The observed distribution of the 185 matched pairs having at least one psychiatric disorder showed a p1 value of 0.52 and a p2 value of 0.51, indicating no selection bias in this study.

    Conclusion

    Our findings support the idea that the use of friend controls can produce a valid basis for a case-control study.

    Mots-clés Pascal : Toxicomanie, Trouble psychiatrique, Biais méthodologique, Amitié, Méthodologie, Homme, Epidémiologie, Etude cas témoin, Brésil, Amérique du Sud, Amérique, Biais sélection

    Mots-clés Pascal anglais : Drug addiction, Mental disorder, Methodological bias, Friendship, Methodology, Human, Epidemiology, Case control study, Brazil, South America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0080509

    Code Inist : 002B30A01A1. Création : 21/05/1997.