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  1. Incidence, natural history and cardiovascular events in symptomatic and asymptomatic peripheral arterial disease in the general population.

    Article - En anglais


    Intermittent claudication is associated with a poor prognosis, but less is known of the risks associated with asymptomatic peripheral arterial disease.

    The aims of this study were to determine the incidence and natural history of claudication, and the incidence of cardiovascular events in symptomatic and asymptomatic peripheral arterial disease.


    In 1988,1592 subjects aged 55-74 years were selected randomly from the age-sex registers of 10 general practices in Edinburgh, Scotland.

    The presence of peripheral arterial disease was determined by the World Health Organization questionnaire on intermittent claudication, the ankle brachial pressure index and a reactive hyperaemia test.

    This cohort was followed prospectively over 5 years for subsequent cardiovascular events and death.


    One hundred and sixteen new cases of claudication were identified (incidence density 15.5 per 1000 person-years).

    Of those with claudication at baseline, 28.8% still had pain after 5 years, 8.2% underwent vascular surgery or amputation, and 1.4% developed leg ulceration. audicants had a significantly increased risk of developing angina compared with normals (RR : 2.31,95% CI : 1.04-5.10), and asymptomatic subjects had a slightly increased risk of myocardial infarction and stroke.

    Deaths from cardiovascular disease were more likely in both claudicants (RR : 2.67,95% CI : 1.34-5.29) and subjects with major (RR : 2.08,95% CI : 1.13-3. (...)

    Mots-clés Pascal : Artère pathologie, Hémodynamique périphérique, Athérosclérose, Claudication, Intermittent, Membre, Mortalité, Morbidité, Incidence, Pronostic, Evolution, Homme, Epidémiologie, Ecosse, Grande Bretagne, Royaume Uni, Europe, Etude cohorte, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Artériopathie oblitérante

    Mots-clés Pascal anglais : Arterial disease, Peripheral hemodynamics, Atherosclerosis, Claudication, Intermittent, Limb, Mortality, Morbidity, Incidence, Prognosis, Evolution, Human, Epidemiology, Scotland, Great Britain, United Kingdom, Europe, Cohort study, Cardiovascular disease, Vascular disease, Occlusive arterial disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0080497

    Code Inist : 002B12B03. Création : 21/05/1997.