The effect of the 1993 European revision of the AIDS case definition in Italy : implications for modelling the HIV epidemic.
To evaluate the effect of the 1993 European AIDS definition on reducing pre-AIDS mortality and to what degree an earlier diagnosis can be made.
Prospective observational study.
All patients diagnosed between January 1993 and December 1994 and reported to the National AIDS Registry from four Italian regions, who met only the new criteria for the 1993 case definition (AIDS-1993) were studied.
Follow-up of patients who did not eventually meet the 1987 definition (AIDS-1987), or had not died from other causes (pre-AIDS-1987 death), was censored at the last available clinical visit before 1 April 1996.
We analysed the data using Kaplan-Meier non-parametric survival analysis and Cox proportional hazards model.
A total of 74 (4.1%) individuals met only the new criteria.
Of these, 49 (62.2%) were men, 42 (56.8%) had pulmonary tuberculosis, 22 (29.7%) had recurrent bacterial pneumonia, and 10 (13.5%) had cervical cancer.
During follow-up, 35 (45.3%) individuals developed an AIDS-1987 disease, and 10 (13.5%) died without fulfilling the AIDS-1987 definition.
Pre-AIDS-1987 death accounted for 22.2% (10 out of 45) of the subsequent outcomes observed prior to 1 April 1996.
Using Kaplan-Meier technique, we estimated that after 9.8 months 50% of these individuals were diagnosed with AIDS-1987 disease, or died without such a diagnosis. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Mortalité, Pronostic, Homme, Définition, Italie, Europe, Immunopathologie, Immunodéficit, Surveillance sanitaire
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Mortality, Prognosis, Human, Definition, Italy, Europe, Immunopathology, Immune deficiency, Sanitary surveillance
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0079188
Code Inist : 002B06D01. Création : 21/05/1997.