Copyright (c) 1996 Elsevier Science B.V. All rights reserved.
The susceptibility patterns to « classic » tuberculous pleuritis can reflect the circulating strains in a society.
The records of patients with « classic » tuberculous pleuritis were reviewed retrospectively.
Eighty-six patients were selected who were hospitalized between January 1990 and April 1994.
Pleural fluid and tissue samples of patients were cultured in Lowenstein-Jensen medium.
The isolated strains were subjected to drug susceptibility testing based on the absolute concentration method.
We obtained 40 positive cultures in 86 patients with « classic » tuberculous pleuritis.
The resistance rate was 75% to one or more drugs, 27.5% to two drugs, 15% to three drugs, and 10% to four drugs.
The resistance rates to isoniazid, rifampicin, streptomycin, and ethambutol were 32.5,55,42.5 and 32.5%, respectively.
The resistance to isoniazid+rifampicin was 7.5%. Our findings indicate that the resistance rates for « classic » tuberculous pleuritis are considerably high, reflecting the currently circulating resistance patterns in our region.
The best regimen for new tuberculous cases and the appropriate regimens for drug-resistant cases should be designed and conducted by a nationwide institution.
Copyright 1996 Elsevier Science B.V.
Mots-clés Pascal : Streptomycine, Ethambutol, Isoniazide, Tuberculose, Mycobactériose, Bactériose, Infection, Poumon, Rifampicine, Homme, In vitro, Sensibilité résistance, Bactéricidie, Résistance traitement, Résistance multiple, Résistance croisée, Rétrospective, Aminoglycoside, Hôpital, Turquie, Asie
Mots-clés Pascal anglais : Streptomycin, Ethambutol, Isoniazid, Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Lung, Rifampicin, Human, In vitro, Sensitivity resistance, Bactericidal effect, Negative therapeutic reaction, Multiple resistance, Cross resistance, Retrospective, Aminoglycoside, Hospital, Turkey, Asia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0079058
Code Inist : 002B02S02. Création : 21/05/1997.