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  1. Peripheral nervous system involvement in systemic sclerosis : the median nerve as target structure.

    Article - En anglais


    To investigate the frequency and the main electrophysiological characteristics of the canalicolar passage nerve involvement in patients with systemic sclerosis (SSc).


    Thirty-two SSc patients were enrolled in the study, classified according to the type (diffuse or limited) and the duration (>/<5 years) of the disease.

    Sensory-motor nerve conduction studies (NCS) of the upper and lower limbs, in particular at the critical canalicolar points, were conducted by recording the Compound Muscular Action Potential (CMAP) and the Sensory Action Potential (sNAP).

    The following parameters were evaluated :

    • Motor Nerve Conduction Velocity (MNCV) and Sensory Nerve Conduction Velocity ;

    • distal and proximal latency of the CMAP and the onset and peak latency of the sNAP ;

    • peak-peak amplitude and negative-peak area of the CMAP and sNAP, and the Terminal Latency Index (TLI) (Terminal Distance/MCNV x Distal latency).


    Four (12.5%) patients had a distal neuropathy of the upper limbs (one with monolateral and two with bilateral involvement of the median nerve and one bilateral involvement of the ulnar nerve).

    Fourteen (43.7%) patients showed a decrement of the median nerve TLI and seven (21.8%) of either the median or the ulnar nerve (Table I).

    Motor and sensitive conduction velocity and latency studies did not show a statistical difference between SSc patients and controls. (...)

    Mots-clés Pascal : Sclérodermie, Homme, Complication, Nerf périphérique pathologie, Prévalence, Epidémiologie, Diagnostic, Pathogénie, Electromyographie, Canal carpien syndrome, Nerf médian, Nerf cubital, Compression, Membre supérieur, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Système nerveux pathologie, Electrodiagnostic, Système ostéoarticulaire pathologie

    Mots-clés Pascal anglais : Scleroderma, Human, Complication, Peripheral nerve disease, Prevalence, Epidemiology, Diagnosis, Pathogenesis, Electromyography, Carpal tunnel syndrome, Median nerve, Cubital nerve, Compression, Upper limb, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Nervous system diseases, Electrodiagnosis, Diseases of the osteoarticular system

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0077597

    Code Inist : 002B07. Création : 21/05/1997.