Organochlorines are persistent and highly lipophilic environmental contaminants which bioaccumulate in the food chain.
Some of these chemicals, 2,2-bis (p-chlorophenyl) - 1,1,1-trichloroethane (DDT) and polychlorinated biphenyls (PCBs), have been suggested to be of significance in the aetiology of breast cancer. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an anti-oestrogen in animal studies and should thus lower the risk of breast cancer.
The other isomers of polychlorinated dibenzo-p-dioxins (PCDDs) or the chemically related polychlorinated dibenzofurans (PCDFs) have not been tested regarding carcinogenesis of the breast.
The purpose of this study was to investigate whether PCDDs or PCDFs influence the risk for breast cancer.
Consecutive patients who underwent surgery for a breast disease between 1993 and 1995 were recruited for the study.
Cases were 22 patients with infiltrative breast cancer and controls were 19 patients operated for a benign breast disease during the same time period.
Approximately 10 g of breast tissue free from tumour was taken from the specimen and frozen until analysis.
Fat was extracted, cleaned and analysed with a high-resolution gas chromatograph coupled to a high-resolution mass spectrometer.
Median concentrations of octachlorinated dibenzo-p-dioxin (OCDD) were 598 (170-14,880) and 396 (103-1,847) pg/g lipid in the cases and in the controls, respectively. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Femelle, Homme, Facteur risque, Dioxine dérivé, Dibenzo-p-dioxine(polychloro), Benzofurane dérivé, Dibenzofurane(polychloro), Etude comparative, Tumeur bénigne, Organochloré, Toxicité, Carcinogène, Epidémiologie, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Female, Human, Risk factor, Dioxin derivatives, Benzofuran derivatives, Comparative study, Benign neoplasm, Organochlorine compounds, Toxicity, Carcinogen, Epidemiology, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0077354
Code Inist : 002B20E02. Création : 21/05/1997.