The role of smoking and other risk factors for cervical neoplasia was investigated in a population-based case-control study of 586 women with histologically verified cervical squamous-cell carcinoma in situ (CIS), and 59 women with invasive squamous-cell cervical cancer from Copenhagen.
Controls were randomly selected from the general female population using the computerized Danish Central Population Register.
After adjustment for a variety of confounding variables, which were all significantly associated with CIS risk and included age, number of partners, proportion of sexually active life without barrier contraceptive use, years with intra-uterine devices, number of births, and age at first episode of genital warts (as a proxy measure for human papillomavirus exposure), current cigarette smoking was found to be significantly associated with CIS [adjusted relative risk (RR)=2.4 ; 95% confidence interval (CI) : 1.7-3.4]. Ex-smokers had a lower, but still significantly increased risk (RR=1.6 ; 95% CI : 1.0-2.7).
A dose-response relationship was present, especially for number of cigarettes smoked per day.
In contrast, the crude estimates showed a weak association between invasive cervical cancer and smoking, which however disappeared after confounder control.
The results of the present study support the hypothesis implicating smoking as a risk factor for CIS.
Mots-clés Pascal : Carcinome, Col utérus, Femelle, Homme, Epidémiologie, Facteur risque, Tabac, Danemark, Europe, Appareil génital femelle pathologie, Col utérus pathologie, Tumeur maligne
Mots-clés Pascal anglais : Carcinoma, Uterine cervix, Female, Human, Epidemiology, Risk factor, Tobacco, Denmark, Europe, Female genital diseases, Uterine cervix diseases, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0077353
Code Inist : 002B20C02. Création : 21/05/1997.