Information on the aetiology of oesophageal cancer in alcohol non-drinkers will help us to understand and quantitate risk factors for the disease in the absence of alcohol.
Out of a total of 316 cases with histologically confirmed incident cancers of the oesophagus, 40 (22 men and 18 women) who described themselves as alcohol non-drinkers were considered.
These patients were compared with 151 alcohol non-drinkers (79 men and 72 women) admitted to hospital for acute, non-neoplastic, non-alcohol-non-smoking-related conditions.
The major risk factor for cancer of the oesophagus in non-drinkers was current elevated cigarette smoking compared with never smokers, the odds ratio (OR) for all current smokers was 3.4 [95% confidence interval (CI), 1.5-8.1]. The OR was 0.8 (95% CI 0.2-3.4) for ex-smokers, 1.3 (95% CI 0.4-4.2) for current smokers of fewer than 20 cigarettes per day and 7.5 (95% CI 2.7-20.4) for current smokers of more than 20 cigarettes per day.
Risk also increased with duration of smoking (OR 4.9 for more than 30 years smoking), and in smokers starting the habit when aged 25 or younger (OR 3.9).
Few years of education and gastrectomy were also associated with elevated risk, while a high fruit intake was associated with reduced risk (OR 0.6 and 0.4, respectively, for 7-13 and>13 portions per week compared with<7). (...)
Mots-clés Pascal : Tumeur maligne, Oesophage, Homme, Epidémiologie, Facteur risque, Tabac, Alimentation, Fruit, Statut socioéconomique, Gastrectomie, Italie, Europe, Appareil digestif pathologie, Oesophage pathologie, Chirurgie
Mots-clés Pascal anglais : Malignant tumor, Esophagus, Human, Epidemiology, Risk factor, Tobacco, Feeding, Fruit, Socioeconomic status, Gastrectomy, Italy, Europe, Digestive diseases, Esophageal disease, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0076973
Code Inist : 002B13A01. Création : 21/05/1997.