Cancer incidence was investigated in a cohort of 700 workers employed at a Connecticut chemical plant between mid-1965 and 1989.
The plant produced a variety of chemicals, including arylamines such as dichlorobenzidine (DCB), o-dianisidine, o-tolidine, but not benzidine.
Benzidine production ceased prior to mid-1965.
The principal finding was a statistically significant increase in the standardized incidence ratio (SIR) for bladder cancer in men (SIR=8.3 ; confidence interval, 3.3 to 17.0).
Based on an exposure classification system developed by a panel of former and current employees, the observed association between bladder cancer cases and exposure to arylamines increased with increasing exposure (SIRs=0.0,5.5,16.4, for none, low, or moderate levels of exposure, respectively).
Smoking probably contributed to the bladder cancer risk, as all case subjects were known to be current or former cigarette smokers.
Mots-clés Pascal : Tumeur maligne, Vessie urinaire, Carcinogène, Exposition professionnelle, Arylamine, Toxicité, Homme, Industrie chimique, Epidémiologie, Incidence, Médecine travail, Connecticut, Etats Unis, Amérique du Nord, Amérique, Appareil urinaire pathologie, Voie urinaire pathologie, Vessie pathologie
Mots-clés Pascal anglais : Malignant tumor, Urinary bladder, Carcinogen, Occupational exposure, Arylamine, Toxicity, Human, Chemical industry, Epidemiology, Incidence, Occupational medicine, Connecticut, United States, North America, America, Urinary system disease, Urinary tract disease, Bladder disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0076119
Code Inist : 002B14D02. Création : 21/05/1997.