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  1. Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships.

    Article - En anglais

    Objectives

    - To determine the frequency of Chlamydia trachomatis genital infection within sexual partnerships using highly sensitive polymerase chain reaction (PCR) amplification and to identify the variables that might modify transmission.

    Design

    - Cross-sectional study of sexual partnerships comparing in vitro culture and PCR amplification for C trachomatis.

    Setting

    - Two outpatient sexually transmitted disease clinics.

    Participants

    - Four hundred ninety-four people in sexual partnerships attending sexually transmitted disease clinics.

    Main Outcome Measure

    - Genital infection with C trachomatis.

    Methods

    - DNA sequencing was performed to examine specific genotypes within and between partnerships.

    Cross-sectional analysis was performed to determine characteristics associated with concordance or discordance of infection with partnerships.

    Results

    - Cultures were positive for C trachomatis in 8.5% of males and 12.9% of females (P=03).

    Using PCR, more infections were identified both in males (14.2%) and in females (15.8%), and the difference in infection rates analyzed by sex was no longer significant.

    In 20.4% of 494 couples, at least 1 partner had PCR results positive for C trachomatis, with a concordant infection rate of 10.7%, significantly higher than the 5.5% concordant infection rate demonstrable by culture (P<. 01).

    Male-female and female-male transmission frequencies were equal (68%). (...)

    Mots-clés Pascal : Chlamydia trachomatis, Chlamydiaceae, Chlamydiales, Bactérie, Infection, Maladie sexuellement transmissible, Réaction chaîne polymérase, Epidémiologie, Fréquence, Diagnostic, Homme, Etats Unis, Amérique du Nord, Amérique, Appareil génital pathologie, Exploration microbiologique, Biologie moléculaire

    Mots-clés Pascal anglais : Chlamydia trachomatis, Chlamydiaceae, Chlamydiales, Bacteria, Infection, Sexually transmitted disease, Polymerase chain reaction, Epidemiology, Frequency, Diagnosis, Human, United States, North America, America, Genital diseases, Microbiological investigation, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0073181

    Code Inist : 002B05B02H. Création : 21/05/1997.