Maternal medications and environmental exposures as risk factors for gastroschisis.
In a case-control study of gastroschisis, we evaluated the risks associated with mother's first-trimester use of medications and with hobby or occupational exposures for 110 cases and 220 controls without a birth defect.
Mothers of cases and controls were age-matched.
For hobby or occupational exposures, we found significantly elevated risks for high levels of solvents (odds ratio (OR)=3.8 ; 95% confidence interval (CI)=1.6-9.2) and for colorants (OR=2.3 ; 95% CI=1.3-4.0).
For medications, we found significantly elevated risks for two strong cyclooxygenase inhibitors, aspirin (OR=4.7 ; 95% CI=1.2-18.1) and ibuprofen (OR=4.0 ; 95% CI=1.0-16.0), but not for acetaminophen, a weak cyclooxygenase inhibitor.
Periconceptional exposure to X rays was also associated with gastroschisis (OR=2.5 ; 95% CI=1.2-5.5), but exposure to antibiotics, antinauseants, sulfonamides, or oral contraceptives was not.
We also found elevated risks for two decongestants, pseudoephedrine (OR=2.1 ; 95% CI=0.8-5.5) and phenylpropanolamine (OR=10.0 ; 95% CI=1.2-85.6).
For the group of all decongestants, including also oxymetazoline and ephedrine, the risk was significantly elevated (OR=2.4 ; 95% CI=1.0-5.4).
Controlling in multivariate analyses for several demographic and pregnancy variables associated with gastroschisis in a previous analysis [Torts et al. (1994) Teratology 50 : 44-53] did not substantially change the level or direction of the associations. (...)
Mots-clés Pascal : Acétylsalicylique acide, Ibuprofène, Paracétamol, Médicament, Exposition professionnelle, Solvant organique, Gestation, Gastroschisis, Facteur risque, Traitement mère, Rayon X, Vasomotricité, Pseudoéphédrine, Phénylpropanolamine, Oxymétazoline, Ephédrine, Décongestionnant nasal, Tératogène, Colorant, Salicylés, Arylacétique acide dérivé, Homme, Epidémiologie, Tératologie, Paroi abdominale, Interaction, Abdomen pathologie, Malformation, Toxicité, Inhibiteur enzyme, Prostaglandin-endoperoxide synthase, Oxidoreductases, Enzyme
Mots-clés Pascal anglais : Acetylsalicylic acid, Ibuprofen, Paracetamol, Drug, Occupational exposure, Organic solvent, Pregnancy, Gastrochisis, Risk factor, Maternal treatment, X ray, Vasomotricity, Pseudoephedrine, Phenylpropanolamine, Oxymetazoline, Nasal decongestant, Teratogen, Dyes, Salicylates, Arylacetic acid derivatives, Human, Epidemiology, Teratology, Abdominal wall, Interaction, Abdominal disease, Malformation, Toxicity, Enzyme inhibitor, Prostaglandin-endoperoxide synthase, Oxidoreductases, Enzyme
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0071623
Code Inist : 002B13D02. Création : 21/05/1997.