The authors investigated whether maternal or paternal periconceptional use of recreational drugs increased the risk of having neural tube defect (NTD) - affected pregnancies using a population-based case-control study of fetuses and liveborn infants with NTDs among 1989-1991 California births.
Face-to-face interviews were conducted with mothers of 538 (88% of eligible) NTD cases and 539 (88%) nonmalformed controls, usually within 5 months of delivery.
Periconceptional maternal use of cocaine (odds ratio (OR)=0.74,95% confidence interval (CI) 0.40-1.4), amphetamines/speed (OR=0.68,95% CI 0.39-1.2), or marijuana (OR=0.64,95% CI 0.43-0.95) or preconceptional use of alcohol as<1 drink/day (OR=0.80,95% CI 0.62-1.0) or =1 drink/day (OR=0.69,95% CI 0.42-1.2) or of cigarettes as<1 pack/day (OR=0.90,95% CI 0.65-1.2) or =1 pack/day (OR=0.59,95% CI 0.36-0.96) did not increase the risk for delivering NTD-affected offspring.
Risks were not substantially altered after adjustment for maternal age, race/ethnicity, vitamin use, education, and household income.
Increased NTD risk was also not generally associated with paternal drug use.
The authors could not discern whether the decreased risks observed for these maternal exposures reflected a true association or were due to reporting bias, a disproportionate number of drug-exposed NTD cases among spontaneous abortuses that could not be ascertained, or some other bias.
Mots-clés Pascal : Substance toxicomanogène, Parent, Toxicité, Anencéphalie, Tératogène, Spina bifida, Epidémiologie, Tabagisme, Ethanol, Embryon, Gestation, Conception, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie congénitale, Malformation, Système ostéoarticulaire pathologie, Rachis pathologie, Californie, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Drug of abuse, Parent, Toxicity, Anencephaly, Teratogen, Spina bifida, Epidemiology, Tobacco smoking, Ethanol, Embryo, Pregnancy, Design, Nervous system diseases, Central nervous system disease, Cerebral disorder, Congenital disease, Malformation, Diseases of the osteoarticular system, Spine disease, California, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0069957
Code Inist : 002B03D. Création : 21/05/1997.