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  1. Health-economic implications of the onset of action of antimanic agents. Discussion.

    Article, Communication - En anglais

    Time Course of Improvement in Acute Mania and Rationale for Drug Selection. Symposium. Dallas, TX (USA), 1996/03/22.


    Three medications, lithium, valproate, and carbamazepine, have been shown to be effective in the treatment of acute mania in randomized, controlled clinical trials.

    Additional research over the past decade has provided data regarding potential differences between these medications according to their time course of onset and clinical predictors of response in acute mania.

    These differences have potential impact on both the choice of medication and the health-economics of the treatment of acute mania.


    Published reports regarding the time course of onset, clinical factors associated with response, and health-economic impact of the treatment of acute mania with lithium, valproate, and carbamazepine were reviewed (PAPERCHASE data base, 1966 to present, terms : bipolar disorder, drug treatment, lithium, valproate, and carbamazepine).


    Valproate, when administered via an oral loading dosage, may have a more rapid onset of action than lithium and carbamazepine.

    Preliminary data suggest that specific clinical factors associated with response differ between the three medications.

    Health-economic studies suggest that treatment of acute mania with valproate may be associated with greater cost savings due to shorter lengths of hospital stay, particularly in patients with mixed mania and rapid cycling.

    Patients treated with the combination of carbamazepine and lithium also had reduced hospital lengths-of-stay in one study. (...)

    Mots-clés Pascal : Manie, Trouble humeur, Chimiothérapie, Traitement, Acide valproïque, Carbamazépine, Lithium, Psychotrope, Relation temps réponse, Posologie, Prescription médicale, Analyse coût, Economie santé, Homme, Thymorégulateur

    Mots-clés Pascal anglais : Mania, Mood disorder, Chemotherapy, Treatment, Valproic acid, Carbamazepine, Lithium, Psychotropic, Time response relation, Posology, Medical prescription, Cost analysis, Health economy, Human

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    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0069110

    Code Inist : 002B02B02. Création : 21/05/1997.