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  1. Prenatal magnesium sulfate exposure and the risk for cerebral palsy or mental retardation among very low-birth-weight children aged 3 to 5 years.

    Article - En anglais

    Objective

    - To examine the relationship between prenatal magnesium sulfate exposure and the risk for cerebral palsy (CP) or mental retardation (MR) among very low-birth-weight (VLBW ;<1500 g) children.

    Secondarily, to investigate the effect of prenatal magnesium sulfate exposure on VLBW infant mortality.

    Design

    - Cohort study with follow-up to 1 year of age ; a subset followed up to 3 to 5 years.

    Setting

    - Twenty-nine Georgia counties, including the 5-county Atlanta metropolitan area.

    Participants

    - All VLBW births (N=1097) occurring during 2 years (1986-1988) ; all metropolitan Atlanta VLBW neonates who survived infancy (N=519).

    Main Outcome Measures

    - Infant mortality as determined from vital statistics records.

    Development of CP or MR by 3 to 5 years of age among metropolitan Atlanta VLBW survivors as determined from the Metropolitan Atlanta Developmental Disabilities Surveillance Program.

    Results

    - For the entire cohort, there was no association between prenatal magnesium sulfate exposure and infant mortality (adjusted rate ratio, 1.02 ; 95% confidence interval [Cl], 0.83-1.25).

    Among Atlanta-born survivors, those exposed to magnesium sulfate had a lower prevalence of CP or MR than those not exposed (CP : magnesium sulfate, 0.9%, no magnesium sulfate, 7.7%, crude odds ratio [OR], 0.11,95% CI, 0.02-0.81 ; MR : magnesium sulfate, 1.8%, no magnesium sulfate, 5.8%, crude OR, 0.30,95% CI, 0.07-1.29). (...)

    Mots-clés Pascal : Infirmité motrice cérébrale, Association, Magnésium sulfate, Arriération mentale, Dépistage, Exposition, Prénatal, Incidence, Facteur risque, Relation activité toxicité, Relation mère petit, Mortalité, Prévention, Etude cohorte, Poids naissance faible, Homme, Enfant, Complication, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Déficience intellectuelle

    Mots-clés Pascal anglais : Cerebral palsy, Association, Magnesium sulfate, Mental retardation, Medical screening, Exposure, Prenatal, Incidence, Risk factor, Activity toxicity relation, Mother young relation, Mortality, Prevention, Cohort study, Low birth weight, Human, Child, Complication, Nervous system diseases, Central nervous system disease, Cerebral disorder, Intellectual deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0065798

    Code Inist : 002B18D08. Création : 21/05/1997.