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  1. Long-term pharmacotherapy in the management of obesity.

    Article - En anglais

    Objectives

    - To examine the rationale for long-term use of medications in the management of obesity, to provide an overview of published scientific information on their safety and efficacy, and to provide guidance to patients and practitioners regarding risks and benefits of treatment.

    Data Sources

    - Original reports and reviews obtained through electronic database searches on anorexiant drugs supplemented by a manual search of bibliographies.

    Study Selection

    - English-language articles that discussed the role of medications in the treatment of human obesity, and studies that evaluated their safety and efficacy for a minimum of 24 weeks.

    Data Extraction

    - Studies were reviewed by experts in the fields of nutrition, obesity, and eating disorders to evaluate study design and the validity of authors'conclusions.

    Data Synthesis

    - The long-term use of medications in the management of obesity is consistent with the current consensus that obesity responds poorly to short-term interventions.

    Net weight loss attributable to medication is modest, ranging from 2 to 10 kg, but patients taking active drug are more likely to lose 10% or more of initial body weight.

    Weight loss tends to reach a plateau by 6 months.

    Weight remains below baseline throughout treatment, although some studies show partial weight regain despite continued drug therapy.

    Most adverse effects are mild and self-limited, but rare serious outcomes have been reported.

    Conclusions

    (...)

    Mots-clés Pascal : Obésité, Conduite à tenir, Long terme, Chimiothérapie, Traitement, Facteur risque, Pharmacocinétique, Pharmacovigilance, Recommandation alimentaire, Synthèse bibliographique, Homme, Prévention, Etat nutritionnel, Trouble nutrition, Organisation santé

    Mots-clés Pascal anglais : Obesity, Clinical management, Long term, Chemotherapy, Treatment, Risk factor, Pharmacokinetics, Pharmacovigilance, Dietary allowance, Bibliographic survey, Human, Prevention, Nutritional status, Nutrition disorder, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0065539

    Code Inist : 002B02N. Création : 21/05/1997.