The effect of cimetidine and ranitidine on cognitive function in postoperative cardiac surgical patients.
To compare the incidence of delirium in postoperative cardiac surgical patients treated with either cimetidine or ranitidine.
Cardiac surgery patients were randomized to receive either cimetidine or ranitidine postoperatively.
Each patient underwent three Mini-Mental Status Examinations (MMSE) and the medical record was reviewed for pertinent past medical history, laboratory data, and evidence of delirium on three occasions : one day preoperatively (before H-2 blocker was given), in the early postoperative period (while receiving the H-2 blocker) ; usually two days postoperatively on the day of hospital discharge (several days after the H-2 blocker had been discontinued).
Overall, both groups in the early postoperative period showed a significant decrease in the MMSE score (27.11 ± 4.44 to 25.38 ± 2.87, mean ± SD ; t=5.16, p<. 0005), which resolved by the time of hospital discharge.
There was no significant difference between cimetidine and ranitidine.
Both age and preoperative MMSE score were strongly associated with the development of delirium.
Conclusions We found no significant difference between cimetidine's versus ranitidine's effect upon cognitive functioning in the postoperative cardiac surgical patient.
This was true even when controlling for age and length of stay.
Mots-clés Pascal : Cimétidine, Chimiothérapie, Ranitidine, Toxicité, Incidence, Délirium, Trouble cognition, Chirurgie, Coeur, Traitement, Test neuropsychologique, Mini Mental State Examination Folstein et al, Epidémiologie, Homme, Antiulcéreux, Antisécrétoire, Antihistaminique, Antagoniste, Récepteur histaminergique H2
Mots-clés Pascal anglais : Cimetidine, Chemotherapy, Ranitidine, Toxicity, Incidence, Delirium, Cognitive disorder, Surgery, Heart, Treatment, Neuropsychological test, Mini Mental State Examination Folstein et al, Epidemiology, Human, Antiulcer agent, Antisecretory agent, Antihistaminic, Antagonist, H2 receptor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0065429
Code Inist : 002B02U01. Création : 21/05/1997.