Metalworking Fluids Symposium. Detroit, Michigan (USA), 1995/11/13.
Acute pulmonary effects of inhalation exposure to (unused) neat and in-use metalworking fluids (MWF) were studied to evaluate the potency of characterized MWF in terms of their effects on breathing and lung inflammation.
Inhalation exposure of guinea pigs caused dose-dependent changes in respiratory rate and volume that were used to quantify potency.
In-use MWF was consistently more toxic than the corresponding neat MWF. significant predictors of respiratory responses were whether MWF was neat or in-use (p=0.0001), exposure concentration (p=0.022), MWF formulation (p=0.031), and the particular in-use MWF tested (p=0.032).
Inhalation exposures to MWF biocides resulted in dose-dependent sensory irritation responses.
Guinea pig studies revealed significant inflammation resulting from MWF exposure marked by change in bronchoalveolar lavage (BAL) fluid from 3% neutrophils (controls) to 60-79% (MWF-exposed) and 25-fold increase in total BAL cells.
The in-use MWF ranged in endotoxin concentration from 280 to 1.7 x 105 endotoxin units (EU)/mL.
To investigate the role of endotoxin, studies were carried out in mice sensitive (SEN) and resistant (RES) to endotoxin.
SEN mice revealed a dose-dependent 10,000-fold increase in BAL neutrophils and a 100-fold increased concentration of interleukin-6 (11-6) and tumor necrosis factor-alpha (TNF-alpha) following inhalation exposure to in-use MWF.
This inflammatory response was not observed with exposure to neat MWF or with sham exposure. (...)
Mots-clés Pascal : Toxicité, Aigu, Huile travail métal, Biocide, Aérosol, Relation dose réponse, Inhalation, Animal, Cobaye, Rodentia, Mammalia, Vertebrata, Souris, Inflammation, Poumon, Appareil respiratoire pathologie, Alvéolobronchique, Endotoxine, Exposition professionnelle, Médecine travail
Mots-clés Pascal anglais : Toxicity, Acute, Metalworking oil, Biocide, Aerosols, Dose activity relation, Inhalation, Animal, Guinea pig, Rodentia, Mammalia, Vertebrata, Mouse, Inflammation, Lung, Respiratory disease, Bronchioalveolar, Endotoxin, Occupational exposure, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0065321
Code Inist : 002B03L06. Création : 21/05/1997.