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  1. Pulmonary effects of machining fluids in guinea pigs and mice.

    Article, Communication - En anglais

    Metalworking Fluids Symposium. Detroit, Michigan (USA), 1995/11/13.

    Acute pulmonary effects of inhalation exposure to (unused) neat and in-use metalworking fluids (MWF) were studied to evaluate the potency of characterized MWF in terms of their effects on breathing and lung inflammation.

    Inhalation exposure of guinea pigs caused dose-dependent changes in respiratory rate and volume that were used to quantify potency.

    In-use MWF was consistently more toxic than the corresponding neat MWF. significant predictors of respiratory responses were whether MWF was neat or in-use (p=0.0001), exposure concentration (p=0.022), MWF formulation (p=0.031), and the particular in-use MWF tested (p=0.032).

    Inhalation exposures to MWF biocides resulted in dose-dependent sensory irritation responses.

    Guinea pig studies revealed significant inflammation resulting from MWF exposure marked by change in bronchoalveolar lavage (BAL) fluid from 3% neutrophils (controls) to 60-79% (MWF-exposed) and 25-fold increase in total BAL cells.

    The in-use MWF ranged in endotoxin concentration from 280 to 1.7 x 105 endotoxin units (EU)/mL.

    To investigate the role of endotoxin, studies were carried out in mice sensitive (SEN) and resistant (RES) to endotoxin.

    SEN mice revealed a dose-dependent 10,000-fold increase in BAL neutrophils and a 100-fold increased concentration of interleukin-6 (11-6) and tumor necrosis factor-alpha (TNF-alpha) following inhalation exposure to in-use MWF.

    This inflammatory response was not observed with exposure to neat MWF or with sham exposure. (...)

    Mots-clés Pascal : Toxicité, Aigu, Huile travail métal, Biocide, Aérosol, Relation dose réponse, Inhalation, Animal, Cobaye, Rodentia, Mammalia, Vertebrata, Souris, Inflammation, Poumon, Appareil respiratoire pathologie, Alvéolobronchique, Endotoxine, Exposition professionnelle, Médecine travail

    Mots-clés Pascal anglais : Toxicity, Acute, Metalworking oil, Biocide, Aerosols, Dose activity relation, Inhalation, Animal, Guinea pig, Rodentia, Mammalia, Vertebrata, Mouse, Inflammation, Lung, Respiratory disease, Bronchioalveolar, Endotoxin, Occupational exposure, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0065321

    Code Inist : 002B03L06. Création : 21/05/1997.