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  1. Folic acid fortification of the food supply : Potential benefits and risks for the elderly population.

    Article - En anglais

    Objective

    - To estimate the potential benefits and risks of food folic acid fortification for an elderly population.

    Benefits are expected through the improvement of folate and homocysteine status, but there is also a risk of masking or precipitating clinical manifestations related to vitamin B12 deficiency with increasing exposure to folic acid.

    Design

    - Cross-sectional analysis, with projected change at various levels of folic acid fortification.

    Setting

    - Participants in the Framingham Heart Study original cohort.

    Participants

    - A total of 747 subjects aged 67 to 96 years who both completed usable food frequency questionnaires and had blood concentrations of B vitamins and homocysteine measured.

    Main Outcome Measures

    - Projected blood folate and homocysteine concentrations and combined high folate intake and low plasma vitamin B12 concentration.

    Results

    - Percentages of this elderly population with folate intake below 400 mug/d are projected to drop from 66% at baseline to 49% with 140 mug of folate per 100 g of cereal-grain product, to 32% with 280 mug, to 26% with 350 mug, and to 11% with 700 mug.

    Percentages with elevated homocysteine concentrations (>14 mumol/L) are projected to drop from 26% at baseline to 21% with 140 mug of folate per 100 g, to 17% with 280 mug, to 16% with 350 mug, and to 12% with 700 mug. (...)

    Mots-clés Pascal : Acide folique, Produit alimentaire enrichi, Association, Ressource alimentaire, Etude transversale, Pharmacocinétique, Population ancestrale, Bénéfice, Facteur risque, Hydroxocobalamine, Complication, Prévention, Homme

    Mots-clés Pascal anglais : Folic acid, Fortified product, Association, Food supply, Cross sectional study, Pharmacokinetics, Ancestral population, Profit, Risk factor, Hydroxocobalamin, Complication, Prevention, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0064696

    Code Inist : 002B29B. Création : 21/05/1997.