- To estimate the potential benefits and risks of food folic acid fortification for an elderly population.
Benefits are expected through the improvement of folate and homocysteine status, but there is also a risk of masking or precipitating clinical manifestations related to vitamin B12 deficiency with increasing exposure to folic acid.
- Cross-sectional analysis, with projected change at various levels of folic acid fortification.
- Participants in the Framingham Heart Study original cohort.
- A total of 747 subjects aged 67 to 96 years who both completed usable food frequency questionnaires and had blood concentrations of B vitamins and homocysteine measured.
- Projected blood folate and homocysteine concentrations and combined high folate intake and low plasma vitamin B12 concentration.
- Percentages of this elderly population with folate intake below 400 mug/d are projected to drop from 66% at baseline to 49% with 140 mug of folate per 100 g of cereal-grain product, to 32% with 280 mug, to 26% with 350 mug, and to 11% with 700 mug.
Percentages with elevated homocysteine concentrations (>14 mumol/L) are projected to drop from 26% at baseline to 21% with 140 mug of folate per 100 g, to 17% with 280 mug, to 16% with 350 mug, and to 12% with 700 mug. (...)
Mots-clés Pascal : Acide folique, Produit alimentaire enrichi, Association, Ressource alimentaire, Etude transversale, Pharmacocinétique, Population ancestrale, Bénéfice, Facteur risque, Hydroxocobalamine, Complication, Prévention, Homme
Mots-clés Pascal anglais : Folic acid, Fortified product, Association, Food supply, Cross sectional study, Pharmacokinetics, Ancestral population, Profit, Risk factor, Hydroxocobalamin, Complication, Prevention, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0064696
Code Inist : 002B29B. Création : 21/05/1997.