Despite many reports of individuals with congenital plasminogen deficiency and thrombosis, there is still uncertainty whether heterozygous deficiency represents a real thrombophilic risk factor or simply a coincidental finding.
We have addressed this issue by testing for plasminogen deficiency in a cohort of 9611 blood donors.
Out of 66 donors with reduced plasminogen activity on two occasions 28 were shown to have a familial deficiency state (including 3 with dysplasminogenaemia).
Our observed prevalence rate for familial plasminogen deficiency, calculated at 2.9/1000 (95% CI=1.9-4.2 per 1000), was not significantly different from that calculated from published reports of congenital plasminogen deficiency in thrombotic cohorts (5.4/1000).
Furthermore, with only two exceptions, all 80 donors and relatives with familial deficiency were asymptomatic with regard to thrombosis - including a 29 year old donor with suspected compound heterozygous hypoplasminogenaemia.
These findings add further weight to the argument that familial heterozygous plasminogen deficiency, at least in isolation, does not constitute a significant thrombotic risk factor.
However, it remains uncertain whether plasminogen deficiency, when combined with other thrombophilic conditions, may become more clinically important.
Mots-clés Pascal : Thrombose, Facteur risque, Epidémiologie, Déficit, t-Plasminogen activator, Serine endopeptidases, Peptidases, Hydrolases, Enzyme, u-Plasminogen activator, Etude familiale, Ecosse, Grande Bretagne, Royaume Uni, Europe, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Thrombosis, Risk factor, Epidemiology, Deficiency, t-Plasminogen activator, Serine endopeptidases, Peptidases, Hydrolases, Enzyme, u-Plasminogen activator, Family study, Scotland, Great Britain, United Kingdom, Europe, Human, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0057549
Code Inist : 002B12B03. Création : 21/05/1997.