Quality assurance/quality control procedures for chlorinated hydrocarbons in human breast adipose tissue.
Extensive literature exists supporting the accumulation of organochlorine pesticides such as DDT 12,2-bis (p-chlorophenyl) - 1,1,1-trichloroethane], and polychlorinated biphenyls (PCBs) in human adipose tissue.
Debate has surfaced concerning the link between these environmental contaminants and human breast cancer.
Accurate residue analysis and proper analytical procedures are critical in determining the extent to which these compounds play a role in human breast cancer.
Further, adequate quality assessment/quality control (QA/QC) is critical for reliable residue analysis.
The purpose of this research was twofold : (1) to find an appropriate surrogate for human breast adipose tissue for spiking purposes, as human samples are difficult to obtain, and (2) to develop a human breast adipose tissue pool that yields adequate reproducibility with low coefficients of variation (CVs) for each compound of interest.
Using a previously validated method developed in the Analytical Laboratory at Colorado State University, rendered ovine adipose tissue was found to be a suitable spiking material, as it was free of interfering compounds and behaved in a manner similar to human breast adipose tissue throughout the analytical method. (...)
Mots-clés Pascal : Méthode étude, Méthode analyse, Accumulation biologique, Résidu, Pesticide, Organochloré, Biphényle(polychloro), Hydrocarbure chloré, Contamination, Tissu adipeux, Femme, Homme, Glande mammaire, Modèle, Animal, Mouton, Artiodactyla, Ungulata, Mammalia, Vertebrata, Analyse routine, Assurance qualité, Contrôle qualité, Surveillance biologique
Mots-clés Pascal anglais : Investigation method, Analysis method, Biological accumulation, Residue, Pesticides, Organochlorine compounds, Polychlorobiphenyl, Chlorocarbon, Contamination, Adipose tissue, Woman, Human, Mammary gland, Models, Animal, Sheep, Artiodactyla, Ungulata, Mammalia, Vertebrata, Routine analysis, Quality assurance, Quality control, Biological monitoring
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0056663
Code Inist : 002B03L06. Création : 21/05/1997.