To assess which factors are associated with the CD4+lymphocyte count at the time of AIDS diagnosis we studied 3046 patients in the AIDS IN EUROPE study who were diagnosed with AIDS in 1 of 17 European countries between 1979 and 1989 and for whom the CD4 count at AIDS diagnosis was known.
Data were extracted retrospectively from patient case notes, using a standardized form.
There was a wide range of average CD4+lymphocyte counts at AIDS diagnosis, according to which diseases were present at diagnosis.
The highest geometric mean CD4+lymphocyte counts at AIDS diagnosis were associated with the diagnosis of extrapulmonary tuberculosis, Kaposi's sarcoma, and non-Hodgkin's lymphoma while the lowest counts were found when histoplasmosis and cytomegalovirus (CMV) retinitis were present.
There were no appreciable differences between CD4+lymphocyte counts at AIDS in patients according to the three major transmission route categories (sex, age, or region of diagnosis) but there was a marked trend (p<0.005) toward lower CD4+lymphocyte counts at AIDS diagnosis in more recent years.
These associations remained largely unchanged after adjustment for other factors.
Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Lymphocyte, Diagnostic, Taux, Homme, Epidémiologie, Europe, Immunopathologie, Immunodéficit, Cellule sanguine, Antigène CD4
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Lymphocyte, Diagnosis, Rate, Human, Epidemiology, Europe, Immunopathology, Immune deficiency, Blood cell
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0055510
Code Inist : 002B06D01. Création : 21/05/1997.