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  1. The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P22 HIV) infection study : Design and methods.

    Article - En anglais

    The P2C2 HIV Study is a prospective natural history study initiated by the National Heart, Lung, and Blood Institute in order to describe the types and incidence of cardiovascular and pulmonary disorders that occur in children with vertically transmitted HIV infection (i.e., transmitted from mother to child in utero or perinatally).

    This article describes the study design and methods.

    Patients were recruited from five clinical centers in the United States.

    The cohort is composed of 205 infants and children enrolled after 28 days of age (Group I) and 612 fetuses and infants of HIV-infected mothers, enrolled prenatally (73%) or postnatally at age<28 days (Group II).

    The maternal-to-infant transmission rate in Group II was 17%. The HIV-negative infants in Group II (Group IIb) serves as a control group for the HIV-infected children (Group IIa).

    The cohort is followed at specified intervals for clinical examination, cardiac, pulmonary, immunologic, and infectious studies and for intercurrent illnesses.

    In Group IIa, the cumulative loss-to-follow-up rate at 3 years was 10.5%, and the 3-year cumulative mortality rate was 24.9%. The findings will be relevant to clinical and epidemiologic aspects of HIV infection in children.

    Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Transmission mère enfant, Poumon pathologie, Appareil circulatoire pathologie, Complication, Enfant, Homme, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Immunopathologie, Immunodéficit, Appareil respiratoire pathologie

    Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Mother to child transmission, Lung disease, Cardiovascular disease, Complication, Child, Human, Epidemiology, United States, North America, America, Immunopathology, Immune deficiency, Respiratory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0054495

    Code Inist : 002B06D01. Création : 21/05/1997.