To determine the demographic/clinical profile of human immunodeficiency virus (HIV) - infected adolescents in care at selected sites.
We mailed surveys requesting prevalence data from physicians in government-funded HIV research and care programs on HIV-infected youth (10-21 years) receiving care.
A total of 49% responses yielded information on 978 subjects.
Vertical, blood, and sexual were predominant transmission modes.
Three-quarters were of an ethnic/racial minority ; 50% were female.
The earliest median CD4 count was 0.467 x 109/liter (467/mul).
Percent asymptomatic varied by transmission : vertical (16%), blood products (40%), male-male sexual (67%) and female-male sexual (M : 73%) (F : 74%). Clinically indicated Pneumocystis carinii pneumonia prophylaxis was differentially prescribed : vertical (96%), blood (89%), and sexual (male-male-47%) (female-male : M : 36% and F : 56%). Of these youth 78% are not represented in national AIDS case data.
Examination of numerator data from selected sites indicates three transmission-driven adolescent HIV epidemics with different characteristics.
Minority youth are disproportionately represented ; many vertically infected infants are surviving to adolescence ; sexual activity is a significant transmission avenue.
HIV-infected youth appear to enter care with considerable immunosuppression.
Clinical profiles and treatment patterns appear to differ by transmission mode. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Séropositivité, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Préadolescent, Homme, Adolescent, Adulte jeune, Démographie, Symptomatologie, Mode transmission, Enquête, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Seropositivity, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Preadolescent, Human, Adolescent, Young adult, Demography, Symptomatology, Transmission mode, Survey, Epidemiology, United States, North America, America, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0053619
Code Inist : 002B06D01. Création : 21/05/1997.