The effect of cigarettes smoking on the blood counts of T and NK cells in subjects with occupational exposure to organic solvents.
The study was carried out in a population of 139 men divided into two control groups ; 40 non-smokers and 39 smokers not exposed to chemical compounds, and two groups exposed to them : 19 non-smokers and 41 cigarette smokers with occupational contact with organic solvents.
The results of toxicological analyses of air and chromatographic analyses of solvents demonstrated the presence of benzene, toluene, xylene and their partly hydrogenated derivatives, paraffin hydrocarbons, oleins, naphthenes (components of painter's naphtha), monohydric and polyhydric alcohols (butanol, cyclohexanol, butylene glycol), esters (ethyleneglycol acetate, butyl acetate) and ketones (methylisobutyl ketone, cyclohexanone).
In the time of the studies the TWA values for benzene were 0 to 38 mg x m-3 (0 to 12 ppm), with arithmetic mean averages of about 19 mg x m-3 (6 ppm) and for the level of benzene 0-351 mg x m-3 (0-110 ppm) with arithmetic mean annual averages of about 48 mg x m-3 (15 ppm).
Mean phenol concentration in the urine of the workers in groups I, II, III and IV respectively was :
7.9 ± 3.5 ;
10.0 ± 5.8 ;
16.8 ± 6.2 and 18.4 ± 9.7 mg x l-1.
Hippuric acid concentration in the urine of the workers in groups I to IV was : 496 ± 326,538 ± 341,982 ± 420 and 1107 ± 507 mg x l-1 respectively.
The absolute counts were determined of T-cells (CD3+), T-helper (CD4+), T-suppressor (CD 8+) celles and natural killer (NK) cells (CD 16+) in the peripheral blood by indirec immunofluorescence. (...)
Mots-clés Pascal : Solvant organique, Exposition professionnelle, Homme, Toxicité, Lymphocyte T, Cellule NK, Cellule helper, Cellule suppressive, Numération, Association toxique, Interaction toxique, Tabagisme, Surveillance biologique, Immunologie, Médecine travail
Mots-clés Pascal anglais : Organic solvent, Occupational exposure, Human, Toxicity, T-Lymphocyte, Natural killer cell, Helper cell, Suppressive cell, Numeration, Toxic association, Poison interaction, Tobacco smoking, Biological monitoring, Immunology, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0050618
Code Inist : 002B03L04. Création : 21/05/1997.