Community studies in Guinea-Bissau have found that exposure to measles prior to 6 months of age is associated with delayed mortality later in childhood.
In an attempt to understand the underlying mechanism, we examined the role of pre-exposure nutritional status and the impact of exposure to measles on growth and subsequent mortality in these outbreaks.
Though exposed children were lighter than controls, there was no association between pre-exposure weight-for-age and subsequent mortality adjusting for age.
Although exposure was strongly associated with excess mortality, it did not have a negative impact on growth.
Adjustment for state of nutrition did not alter the mortality ratio (MR) between 6 and 59 months of age for exposed children and controls ; exposed children examined anthropometrically between 6-17 months had a MR of 3.70 compared with controls.
This trend was the same for anthropometric measurements obtained at 18-59 months of age.
Among the controls, there was a significant association between weight-for-age and subsequent mortality to the age of 5 years.
However, for exposed children there was no association ; the relation between weight-for-age and subsequent mortality was significantly different for exposed children compared with controls (tests for interaction between exposure and anthropometric measurements at 6-17 months : P=0.05). (...)
Mots-clés Pascal : Nourrisson, Homme, Rougeole, Virose, Infection, Mortalité, Etat nutritionnel, Zone tropicale, Guinée Bissau, Afrique
Mots-clés Pascal anglais : Infant, Human, Measles, Viral disease, Infection, Mortality, Nutritional status, Tropical zone, Guinea-Bissau, Africa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0049550
Code Inist : 002B05C02B. Création : 21/05/1997.