Despite evidence from animal studies for a protective effect of higher calcium and possibly vitamin D intake against colorectal cancer, epidemiologic studies have been inconclusive.
We investigated the associations between the intake of calcium and vitamin D and the occurrence of colorectal cancer.
In a prospective study, 89448 female registered nurses who were free of cancer responded to a mailed, semiquantitative food-frequency questionnaire in 1980 ; dietary information was updated in 1984 and 1986.
Through 1992,501 incident cases of colorectal cancer (396 colon and 105 rectal cancers) were documented.
As measures of exposure, we used nutrient intake in 1980 and also two measures of long-term intake on the basis of the three questionnaires : the average of intakes from the three questionnaires and consistent intakes, which were defined as high if women were in the upper tertile on all questionnaires and low if they were in the lower tertile on all questionnaires.
To further characterize long-term intake, we conducted analyses excluding women who reported a change in their consumption of milk (primary source of calcium and vitamin D) in the 10 years prior to 1980.
Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using the lowest quintile of intake as a reference.
The Mantel extension test was used to evaluate linear trends across the categories of nutrient intake. (...)
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Epidémiologie, Analyse risque, Protection, Vitamine D, Calcium, Régime alimentaire, Analyse corrélation, Homme, Femelle, Elément minéral, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Epidemiology, Risk analysis, Protection, Vitamin D, Calcium, Diet, Correlation analysis, Human, Female, Inorganic element, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0049145
Code Inist : 002B13B01. Création : 21/05/1997.