Four cases of pituitary adenoma among employees at a primary aluminum production factory were identified over a five year period by a community physician.
The objective of this investigation was to determine whether there has been a comparable high incidence in other aluminum factories, and if particular jobs, departments, or activities in the industry are associated with higher rates of the disease.
Method-Pituitary adenoma in employees at all United States factories of the company for the years 1989-94 was assessed by a search of a health data information bank and an insurance data base covering present and past employees of the corporation.
The incidence in the aluminum workers was estimated and compared with the workers in the index plant.
A nested case control study was conducted to compare employment histories of identified cases with those of age and sex matched controls selected from the health information data base.
25 cases, including the index cases, were identified which had been diagnosed during the period 1989-94.
The resulting rate of 10.4/100 000 person-years was much lower than that at the index plant.
Case-control analysis showed no coherent pattern of location, department, or job significantly associated with risk.
In particular, jobs and departments associated with exposures common to aluminum smelting-such as coal tar pitch volatiles and fluorides-were shown to be uncommon among cases compared with age and sex matched controls. (...)
Mots-clés Pascal : Aluminium, Exposition professionnelle, Toxicité, Adénome, Hypophyse, Homme, Analyse amas, Epidémiologie, Facteur risque, Industrie, Médecine travail, Etats Unis, Amérique du Nord, Amérique, Hypophyse pathologie, Endocrinopathie, Tumeur bénigne
Mots-clés Pascal anglais : Aluminium, Occupational exposure, Toxicity, Adenoma, Pituitary gland, Human, Cluster analysis, Epidemiology, Risk factor, Industry, Occupational medicine, United States, North America, America, Pituitary diseases, Endocrinopathy, Benign neoplasm
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0046246
Code Inist : 002B03L05. Création : 21/05/1997.