Lymphohaematopoietic malignancies and quantitative estimates of exposure to benzene in Canadian petroleum distribution workers.
To evaluate the relation between mortality from lymphohaematopoietic cancer and long term, low level exposures to benzene among male petroleum distribution workers.
Methods-This nested case control study identified all fatal cases of lymphohaematopoietic cancer among a previously studied cohort.
Of the 29 cases, 14 had leukaemia, seven multiple myeloma, and eight non-Hodgkin's lymphoma.
A four to one matching ratio was used to select a stratified sample of controls from the same cohort, controlling for year of birth and time at risk.
Industrial hygienists estimated workplace exposures for benzene and total hydrocarbons, without knowledge of case or control status, for combinations of job, location, and era represented in all work histories.
Average daily benzene concentrations ranged from 0.01 to 6.2 parts per million (ppm) for all jobs.
Company medical records were used to abstract information on other potential confounders such as cigarette smoking, although the data were incomplete.
Odds ratios (ORs) were calculated with conditional logistic regression techniques for several exposure variables.
Risks of leukaemia, non-Hodgkin's lymphoma, and multiple myeloma were not associated with increasing cumulative exposure to benzene or total hydrocarbons.
For leukaemia, the logistic regression model predicted an OR of 1.002 (P<0.77) for each ppm-y of exposure to benzene. (...)
Mots-clés Pascal : Benzène, Exposition professionnelle, Toxicité, Lymphome non hodgkinien, Myélome, Leucémie, Homme, Mortalité, Camion citerne, Conducteur véhicule, Dose faible, Long terme, Médecine travail, Hémopathie maligne, Lymphoprolifératif syndrome, Canada, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Benzene, Occupational exposure, Toxicity, Non Hodgkin lymphoma, Myeloma, Leukemia, Human, Mortality, Tank truck, Vehicle driver, Low dose, Long term, Occupational medicine, Malignant hemopathy, Lymphoproliferative syndrome, Canada, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0045661
Code Inist : 002B03L06. Création : 21/05/1997.