Airway responsiveness, respiratory symptoms, and exposures to soluble oil mist in mechanical workers.
Objectives-To assess the relation between measured levels of exposure to soluble oil mists in a plant manufacturing ball bearings, and both respiratory symptoms and airway responsiveness in the workforce.
Methods-114 male workers exposed to oil mist and 55 unexposed male controls from nearby factories were studied.
Soluble oil mist concentrations were measured with area samplers.
Respiratory symptoms were assessed by questionnaire and measurement of airway responsiveness to methacholine with an abbreviated method.
Subjects were labelled positive to methacholine airway challenge (MAC+) if forced expiratory volume in one second (FEV1) fell by = 20%. The linear dose-response slope was calculated as the percentage fall in FEV1 at the last dose divided by the total dose given.
Geometric mean concentrations of oil mists ranged from 0.65 mg/m3 (GSD 1.29) to 2.20 mg/m3 (GSD 1.55) based on 92 measurements obtained from 1979-93.
The prevalence of chronic cough or phlegm, bouts of bronchitis, and dyspnoea was greater among exposed workers than among controls (odds ratio (OR) 4.64, P=0.002 for chronic cough and phlegm).
After adjustment for smoking and age, dyspnoea was significantly related to an index of cumulative exposure to oil mist (OR 1.44, P=0.006/10 y. mg/m3).
The proportion of MAC+subjects was similar in the two groups. (...)
Mots-clés Pascal : Brouillard huile, Huile minérale, Roulement bille, Appareil respiratoire pathologie, Toxicité, Hypersensibilité, Epidémiologie, France, Europe, Exposition professionnelle, Métallurgie, Médecine travail, Homme
Mots-clés Pascal anglais : Oil mist, Mineral oil, Ball bearing, Respiratory disease, Toxicity, Hypersensitivity, Epidemiology, France, Europe, Occupational exposure, Metallurgy, Occupational medicine, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0045267
Code Inist : 002B03L06. Création : 21/05/1997.