To determine the prevalence of Staphylococcus aureus nasal carriage and to compare antibody responses to two superantigens, staphylococcal toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxin A (SEA), in rheumatoid arthritis patients and normal subjects.
Methods-88 rheumatoid arthritis patients and 110 control subjects were cultured for nasal carriage of S aureus ; 62 isolates were bacteriophage typed.
Twenty five patients and 11 spouses were tested for antibodies to TSST-1, SEA, and sonicate extracts of Bacteroides fragilis and Escherichia coli ; 19 patients were HLA-DR typed.
50% of patients and 33% of normal subjects were S aureus carriers.
Bacteriophage typing of isolates suggested significant differences between strains isolated from the two groups.
Patients showed higher IgG (P=0.0025) and IgA (P=0.0372) antibody levels to TSST-1 than normal spouses and these responses were not related to rheumatoid factor titres or HLA-DR type.
Conclusions-When compared to normals, rheumatoid arthritis patients more often carry S aureus in their nasal vestibule, carry a distinct subpopulation of S aureus strains, and have higher average antibody levels to TSST-1.
Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Pathogénie, Physiopathologie, Réponse immune, Immunité humorale, Staphylococcus aureus, Micrococcaceae, Micrococcales, Bactérie, Toxine, Superantigène, Antigène, Porteur, Nasopharynx, Epidémiologie, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune, Protéine TSST1
Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Pathogenesis, Pathophysiology, Immune response, Humoral immunity, Staphylococcus aureus, Micrococcaceae, Micrococcales, Bacteria, Toxin, Superantigen, Antigen, Carrier, Nasopharynx, Epidemiology, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0042244
Code Inist : 002B15D. Création : 21/05/1997.