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  1. Melanoma in childhood : An EORTC-MCG multicenter study on the clinico-pathological aspects.

    Article - En anglais

    Melanoma in children is rare.

    Nevertheless, it is imperative that clinicians be aware that melanoma does occur in childhood.

    Yet there is very little information available on the clinico-pathologic variations, and the prognostic parameters of melanoma in children.

    This report presents the results of a multicenter study of 102 lesions originally diagnosed as cutaneous melanoma, conducted among 5 Western European countries and collected during the period 1961-1994.

    Criteria for inclusion in the study included :

    • (I) diagnosis of cutaneous melanoma ;

    • (2) age up to 16 years at diagnosis ;

    • and (3) availability of representative microscopic slides.

    On the basis of the histologic review only, 60 lesions were confirmed as melanoma, and 42 lesions initially diagnosed as melanoma were reclassified as nevi ; 31 of the latter contained a predominance of spindle cells.

    The only significant parameter associated with the development of metastases or fatal outcome was thickness of more than 2.00 mm.

    The 5-year survival rate observed in this study was 84%. Based on these findings we conclude that considerable over-diagnosis of melanomas in children occurs. (...)

    Mots-clés Pascal : Mélanome malin, Peau, Dosage, Adolescent, Homme, Epidémiologie, Diagnostic différentiel, Naevus, Histologie, Grade histologique, Stade clinique, Etude multicentrique, Tumeur maligne, Peau pathologie, Anatomopathologie

    Mots-clés Pascal anglais : Malignant melanoma, Skin, Assay, Adolescent, Human, Epidemiology, Differential diagnostic, Nevus, Histology, Histological grading, Clinical stage, Multicenter study, Malignant tumor, Skin disease, Pathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0042086

    Code Inist : 002B08A. Création : 21/05/1997.