In this study, 1,000 Japanese male alcoholics were consecutively screened by upper gastrointestinal endoscopy with esophageal iodine staining.
Associations among cancer-detection rates, drinking and smoking habits, and aldehyde dehydrogenase-2 (ALDH2) genotypes were evaluated.
A total of 53 patients (5.3%) had histologically confirmed cancer.
Esophageal cancer was diagnosed in 36, gastric cancer in 17, and oropharyngolaryngeal cancer in 9 patients : 8 of the esophageal-cancer patients were multiple-cancer patients, with additional cancer (s) in the stomach and/or oropharyngolaryngeal region.
Multiple logistic regression revealed that use of stronger alcoholic beverages (whisky or shochu) in contrast with lighter beverages (sake or beer) and smoking of 50 pack-years or more increased the risks for esophageal (odds ratio 3.2 and 2.8 respectively), oropharyngolaryngeal (4.8 and 5.1 respectively) and multiple cancer (10.5 and 11.8 respectively).
The inactive form of ALDH2, encoded by the gene ALDH2* 1/*2 prevalent in Orientals, exposes them to higher blood levels of acetaldehyde, a recognized animal carcinogen, after drinking.
This inactive ALDH2 was detected in 19/36 (52.8%) patients with esophageal cancer, in 5/9 (55.6%) patients with oropharyngolaryngeal cancer, and in 7/8 (87.5%) patients with multiple cancer.
All of these gene frequencies far exceeded that in a large alcoholic cohort (80/655,12.2%). (...)
Mots-clés Pascal : Tumeur maligne, Voie aérodigestive supérieure, Estomac, Oesophage, Homme, Dépistage, Intoxication, Ethanol, Tabac, Facteur risque, Génotype, Aldehyde dehydrogenase (NAD+), Oxidoreductases, Enzyme, Japon, Asie, ORL pathologie, Estomac pathologie, Appareil digestif pathologie, Oesophage pathologie
Mots-clés Pascal anglais : Malignant tumor, Upper aerodigestive tract, Stomach, Esophagus, Human, Medical screening, Poisoning, Ethanol, Tobacco, Risk factor, Genotype, Aldehyde dehydrogenase (NAD+), Oxidoreductases, Enzyme, Japan, Asia, ENT disease, Gastric disease, Digestive diseases, Esophageal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0042085
Code Inist : 002B10B01. Création : 21/05/1997.