Postprandial hormone and metabolic responses in simulated shift work.
This study was designed to investigate postprandial responses to a mixed meal in simulated shift work conditions.
Nine normal healthy subjects (six males and three females) were studied on two occasions at the same clock time (1330 h) after consuming test meals, first in their normal environment and secondly after a 9 h phase advance (body clock time 2230 h).
Plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), triacylglycerol (TAG) and non-esterified fatty acids (NEFAs) were determined at intervals for 6 h after each test meal.
Postprandial plasma glucose, insulin, GIP and GLP-1 profiles were evaluated by calculating areas under the curve (AUC) for the first 2 h and the last 4 h of the sampling together with total AUC.
Significantly higher postprandial glucose responses (total AUC) were observed after the phase shift than before (AUC 0-360 min, 2.01 (1.51-2.19) vs 1.79 (1.56-2.04) mmol/l. min ; P<0.02 ; mean (range)). No significant difference was observed when the first 2 h of each response was compared, but significantly higher glucose levels were observed in the last 4 h of the study after the phase shift than before (AUC 120-360 min, 1.32 (1.08-1.42) vs 1.16 (1.00-1.28) mmol/l. min ; P<0.05).
Similar results were obtained for insulin (AUC 0-360 min, 81.72 (30.75-124.97) vs 58.98 (28.03-92.57) pmol/l. min ; P<0.01 ; AUC 120-360 min, 40.73 (16.20-65.25) vs 25.71 (14.25-37.33) pmol/l. min ; P<0.02). (...)
Mots-clés Pascal : Travail posté, Repas, Cellule B, Régulation hormonale, Rythme circadien, Trouble fonctionnel, Métabolisme, Glucose, Lipide, Postprandial, Médecine travail, Pancréas endocrine, Homme
Mots-clés Pascal anglais : Shift work, Meal, B-Cell, Hormonal regulation, Circadian rhythm, Dysfunction, Metabolism, Glucose, Lipids, Postprandial, Occupational medicine, Endocrine pancreas, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0040781
Code Inist : 002B29C01. Création : 21/05/1997.