Excess risk of primary liver cancer in patients with diabetes mellitus.
Chronic infection with hepatitis B virus, alcohol consumption, and cirrhosis of the liver are recognized risk factors for primary liver cancer.
A few, but not all, studies have suggested that diabetes mellitus also increases risk for this cancer.
We conducted a population-based cohort study to analyze the risk of developing primary liver cancer and biliary tract (gallbladder, extrahepatic bile ducts, and ampulla of Vater) cancers among patients with diabetes.
A cohort of 153 852 patients with a hospital discharge diagnosis of diabetes in the period from 1965 through 1983 was identified by use of the Swedish In-patient Register.
Follow-up for these patients extended from the date of cohort entry through December 31,1989.
Incident cases of cancer during follow-up were identified through the Swedish Cancer Registry.
To minimize the impact of selection bias, we excluded from the analysis patients who were diagnosed with liver and biliary tract cancers during the first year of follow-up.
Standardized incidence ratios (SIRs) and their 95% confidence intervals (CIs) were computed by use of nationwide rates of liver and biliary tract cancers, adjusted for age, sex, and calendar year, for comparison.
During 1-24 years of follow-up, 819 incident cancers in the combined category of primary liver (n=533) and biliary tract (n=286) were identified in the cohort, yielding an overall SIR of 2.5 (95% CI=2.3-2.6). (...)
Mots-clés Pascal : Tumeur maligne, Foie, Voie biliaire extrahépatique, Vésicule biliaire, Homme, Diabète, Facteur risque, Epidémiologie, Etude cohorte, Etude longitudinale, Long terme, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie, Endocrinopathie
Mots-clés Pascal anglais : Malignant tumor, Liver, Extrahepathic bile duct, Gallbladder, Human, Diabetes mellitus, Risk factor, Epidemiology, Cohort study, Follow up study, Long term, Digestive diseases, Hepatic disease, Biliary tract disease, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0038821
Code Inist : 002B14C01. Création : 21/05/1997.