Serologic association between human papillomavirus type 16 infection and esophageal cancer in Shaanxi province, China.
The existence of large geographic variations in the prevalence of esophageal cancer in some countries, such as China, indicates that environmental risk factors may be important in the development of this disease.
Some studies have implicated genital-mucosal strains of human papillomaviruses (HPVs) in the etiology of this cancer.
We conducted a case-control study in Shaanxi Province, China, an area with a population at high risk for esophageal cancer, to assess the association of this disease with infection by HPV type 16 (HPV16), the most common cancer-associated genital-mucosal HPV type.
Ninety individuals with esophageal cancer and 121 cancer-free control subjects were identified among the patients in two hospitals in Xi'an, Shaanxi Province.
The control subjects were matched to the case patients on the basis of age and sex.
Blood specimens were drawn from all study subjects, and serum was isolated by routine methods.
The presence of HPV16 antibodies in serum samples was determined by use of an enzyme-linked immunosorbent assay (ELISA) that used baculovirus-derived HPV16 virus-like particles as the antigen.
A similar ELISA that used bovine papillomavirus type 1 (BPV1) virus-like particles as the antigen controlled for the specificity of HPV16 seroreactivity.
Data from the HPV16 and the BPV1 assays were normalized with respect to results obtained in each assay with a control serum of known HPV16 seroreactivity. (...)
Mots-clés Pascal : Tumeur maligne, Oesophage, Homme, Epidémiologie, Facteur risque, Facteur milieu, Virose, Infection, Papillomavirus humain 16, Papillomavirus, Papovaviridae, Virus, Chine, Asie, Echelon provincial, Etude cas témoin, Appareil digestif pathologie, Oesophage pathologie
Mots-clés Pascal anglais : Malignant tumor, Esophagus, Human, Epidemiology, Risk factor, Environmental factor, Viral disease, Infection, Human papillomavirus 16, Papillomavirus, Papovaviridae, Virus, China, Asia, Provincial scope, Case control study, Digestive diseases, Esophageal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0038820
Code Inist : 002B14A01. Création : 21/05/1997.