Patients with parkinsonism can be classified as clinical definite, probable, possible, or unlikely Parkinson's disease (PD).
Possible PD includes patients with PD according to conventional diagnostic criteria and with at least a moderate response to dopamine agonists.
However, these patients have clinical features that may reduce the probability for idiopathic PD.
The objective of this study was to clinically characterize patients with possible disease in a prevalence study of PD and to indicate the frequency of idiopathic PD in this group of patients.
The diagnostic re-evaluation was based on detailed MRI examinations and investigations of dopaminergic drug response after several years of treatment.
In a community-based prevalence study in Norway, comprising 245 PD patients, we found 36 patients (15%) with clinical possible PD.
The patients with possible disease had significant and clinically important differences in demographic and disease characteristics compared to patients with definite and probable PD.
Possible PD patients were older at disease onset, more disabled, and had more neurobehavioral disorders.
MRI examinations of 14 of the 36 patients with possible PD in the prevalence study revealed significant group effects compared to an age-matched control group, with reduced pars compacta width and increased cortical atrophy. (...)
Mots-clés Pascal : Parkinson maladie, Parkinsonisme, Prévalence, Epidémiologie, Imagerie RMN, Antiparkinsonien, Chimiothérapie, Traitement, Agoniste, Récepteur dopaminergique, Lévodopa, Vieillard, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Extrapyramidal syndrome, Maladie dégénérative
Mots-clés Pascal anglais : Parkinson disease, Parkinsonism, Prevalence, Epidemiology, Nuclear magnetic resonance imaging, Antiparkinson agent, Chemotherapy, Treatment, Agonist, Dopamine receptor, Levodopa, Elderly, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Extrapyramidal syndrome, Degenerative disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0038334
Code Inist : 002B18E. Création : 21/05/1997.