To determine the risk factors of the myelodysplastic syndromes (MDS) we conducted a case-control study in Japan.
One hundred and sixteen MDS patients were diagnosed from 1 September to 31 October 1992 and from 1 August to 31 October 1993 in the 32 hospitals enrolled in the Idiopathic Disorders of Hematopoietic Organs Research Commitee.
Age, sex, and hospital-matched controls were selected for each case.
Information on cigarette smoking and drinking habits, hair dye use, history of keeping pet animals, and occupational exposures to organic solvents, lead and radiation was obtained from self-administered questionnaires.
Conditional logistic regression was applied to this individually matched case-control study and odds ratios (ORs) were computed to estimate association between each exposure variable and risk of MDS.
Alcohol drinking was associated with increased risk of MDS (OR=2.15 ; 95% confidence interval=1.12-4.16) and there was a significant trend in risk with increasing amounts of ethanol consumed per week (P<0.05).
We also found elevated ORs for cigarette smokers (OR=1.80), users of hair dye products (OR=1.77), and workers exposed to organic solvents (OR=1.50), although these ratios were not statistically significant.
Exposure to pet animals was not associated with risk of MDS. (...)
Mots-clés Pascal : Myélodysplasique syndrome, Facteur risque, Epidémiologie, Exposition professionnelle, Solvant organique, Composé chimique, Alcoolisme, Tabagisme, Teinture capillaire, Etude cas témoin, Japon, Asie, Homme, Hémopathie maligne, Maladie professionnelle, Médecine travail
Mots-clés Pascal anglais : Myelodysplastic syndrome, Risk factor, Epidemiology, Occupational exposure, Organic solvent, Chemical compound, Alcoholism, Tobacco smoking, Hair dye, Case control study, Japan, Asia, Human, Malignant hemopathy, Occupational disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0038037
Code Inist : 002B19B. Création : 21/05/1997.