Analysis of live, oral poliovirus vaccine monopools for human immunodeficiency virus type 1 and Simian immunodeficiency virus.
Although there is no evidence for transmission of mammalian retroviruses to humans via vaccine immunization, the allegations of contamination of oral poliovirus vaccines with human immunodeficiency virus (HIV) type 1 or a hypothetical progenitor virus from monkeys has created controversy and dispute regarding the origin of AIDS in humans.
Twelve monovalent lots of live, attenuated oral poliovirus vaccine types 1,2, and 3, which were released for use by a North American manufacturer between 1976-1989, were tested for the presence of HIV-1 and simian immunodeficiency virus (SIV).
HIV/SIV were not detected in these monovalent poliovirus vaccine lots with the reverse transcriptase assay, a general detection assay, and highly sensitive and specific polymerase chain reaction assays.
Mots-clés Pascal : Poliovirus, Enterovirus, Picornaviridae, Virus, Contamination biologique, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus immunodéficience simienne, Exploration microbiologique, Réaction chaîne polymérase, Voie orale, Vaccin, Etats Unis, Amérique du Nord, Amérique, Souche atténuée, RNA-directed DNA polymerase, Nucleotidyltransferases, Transferases, Enzyme, Prévention, Immunoprophylaxie
Mots-clés Pascal anglais : Poliovirus, Enterovirus, Picornaviridae, Virus, Biological contamination, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Simian immunodeficiency virus, Microbiological investigation, Polymerase chain reaction, Oral administration, Vaccine, United States, North America, America, Attenuated strain, RNA-directed DNA polymerase, Nucleotidyltransferases, Transferases, Enzyme, Prevention, Immunoprophylaxis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0034063
Code Inist : 002B05C02A. Création : 21/05/1997.