Several studies have shown that human immunodeficiency virus type 1 (HIV-1) is associated with an increase in the incidence of Kaposi's sarcoma and non-Hodgkin's lymphoma among homosexual men.
The role of HIV-1 in increasing the incidence of other malignancies is more controversial.
The incidence of non-Kaposi's sarcoma cancer was examined from 1978 to 1990 among 15,565 homosexual men who participated in studies of hepatitis B virus infection in the late 1970s in New York City, New York, and San Francisco, California.
The standardized incidence ratio (SIR) for all cancers was 1.6 (95% confidence interval (CI) 1.4-1.8).
Excesses were observed for non-Hodgkin's lymphoma (SIR=12.7 ; 95% CI 11.0-14.6), Hodgkin's disease (SIR=2.5 ; 95% CI 1.5-3.9), and anal cancer (SIR=24.2 ; 95% CI 13.5-39.9).
As seen with non-Hodgkin's lymphoma, a cancer known to be associated with HIV-1, Hodgkin's disease incidence was significantly higher in more recent years compared with earlier years.
No cases of Hodgkin's disease were found among HIV-1 antibody-negative men, and Hodgkin's disease was diagnosed near the time of initial acquired immunodeficiency syndrome diagnoses.
Anal cancer incidence did not correlate with HIV-1 antibody status and did not tend to occur near the time of AIDS diagnoses.
This study confirms the association of non-Hodgkin's lymphoma with HIV-1 infection and suggests an association between Hodgkin's disease and HIV-1 infection. (...)
Mots-clés Pascal : Tumeur maligne, Homosexualité, Comportement sexuel, SIDA, Virose, Infection, Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Kaposi maladie, Lymphome non hodgkinien, Epidémiologie, Incidence, Homme, Etats Unis, Amérique du Nord, Amérique, Peau pathologie, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Malignant tumor, Homosexuality, Sexual behavior, AIDS, Viral disease, Infection, HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, Kaposi sarcoma, Non Hodgkin lymphoma, Epidemiology, Incidence, Human, United States, North America, America, Skin disease, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0031186
Code Inist : 002B06D01. Création : 21/05/1997.