Evaluation of Butadiene and Isopropene Health Risks. International Symposium. Blaine, Washington (USA), 1995/06/27.
Although 1,3-butadiene (BD) has been classified as an animal carcinogen, epidemiologic research has reported inconsistent results on the relationship between BD and lymphopoietic and other cancers in humans.
This study evaluated the mortality experience of 15649 men employed for at least 1 year at any of eight North American styrene-butadiene rubber (SBR) plants.
About 75% of the subjects were exposed to BD ; 83% were exposed to styrene (STY).
During 1943-1991, the cohort had a total of 386 172 and an average of 25 person-years of follow-up, with 3976 deaths observed compared to 4553 deaths expected based on general population mortality rates (standardized mortality ratio (SMR)=87,95% confidence interval (Cl)=85-90).
More than expected leukemia deaths occurred in the overall cohort (48 observed/37 expected, SMR=131, Cl=97-174) and among ever hourly subjects (45/32, SMR=143, Cl=104-191).
The excess was concentrated among ever hourly subjects with 10+years worked and 20+years since hire (28/13, SMR=224, Cl=149-323) and among subjects in polymerization (15/6.0, SMR=251, Cl=140-414), maintenance labor (13/4.9, SMR=265, Cl=141-453) and laboratories (10/2.3, SMR=431, Cl=207-793), three areas with potential for relatively high exposure to BD or STY monomers. (...)
Mots-clés Pascal : Industrie caoutchouc, Butadiène, Exposition professionnelle, Mortalité, Epidémiologie, Toxicité, Homme, Carcinogène, Médecine travail
Mots-clés Pascal anglais : Rubber industry, Butadiene, Occupational exposure, Mortality, Epidemiology, Toxicity, Human, Carcinogen, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0027917
Code Inist : 002B04E02. Création : 21/05/1997.