Evaluation of Butadiene and Isopropene Health Risks. International Symposium. Blaine, Washington (USA), 1995/06/27.
Retrospective, quantitative estimates of exposure to 1,3-butadiene, styrene and benzene were developed for a follow-up study of leukemia mortality among 16610 subjects employed at six North American styrene-butadiene rubber manufacturing plants (418846 person-years, 58 leukemia deaths).
The estimation procedure entailed identifying work areas within each manufacturing process, historical changes in exposure potential and specific tasks involving exposure, and using mathematical models to calculate job-and time-period-specific average exposures.
The resulting estimates were linked with the subjects'work histories to obtain cumulative exposure estimates, which were employed in stratified and Poisson regression analyses of mortality rates.
Mantel-Haenszel rate ratios adjusted by race, age, and cumulative styrene exposure increase with cumulative butadiene exposure from 1 in the nonexposed category to 4.5 in the category of 80 ppm-years or more (P=0.01).
The risk pattern is less clear and statistically nonsignificant for styrene exposure.
A trend of increasing risk with butadiene exposure is still present after exclusion of the nonexposed category (P=0.03).
A parsimonious interpretation of the findings presented here, in light of previous epidemiologic studies, is that exposure to butadiene in the synthetic rubber industry produces a dose-related increase in the occurrence of leukemia.
Mots-clés Pascal : Leucémie, Exposition professionnelle, Butadiène, Styrène, Benzène, Carcinogène, Homme, Epidémiologie, Mortalité, Toxicité, Industrie caoutchouc, Médecine travail, Hémopathie maligne
Mots-clés Pascal anglais : Leukemia, Occupational exposure, Butadiene, Styrene, Benzene, Carcinogen, Human, Epidemiology, Mortality, Toxicity, Rubber industry, Occupational medicine, Malignant hemopathy
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0027916
Code Inist : 002B19B. Création : 21/05/1997.