Evaluation of Butadiene and Isopropene Health Risks. International Symposium. Blaine, Washington (USA), 1995/06/27.
This is a further update of a cohort mortality study of 2795 male workers employed at least 6 months between 1942 and 1994 at a 1,3-butadiene facility.
Earlier reports on this cohort found a statistically significant deficit for all causes of death and lower than expected mortality for most leading causes of death.
Prior reports noted an excess of deaths from lymphosarcoma primarily in those employed less than 10 years, first employed before 1946, and employed in jobs with the potential for daily exposure to butadiene (BD).
There was a nonsignificant elevation for leukemia in persons potentially exposed to BD on an intermittent basis.
The purpose of this update was to examine the patterns of mortality with four additional years of follow-up.
Persons who had become eligible since the cohort was last updated through 1990 were also added.
A total of 1222 deaths were identified, and death certificates were obtained for all but 20 of the deaths (1.6%). The standardized mortality ratio (SMR) for all causes of death is 88 (95% confidence interval (Cl)=83-93), and for all cancer, the SMR is 92 (95% Cl=82-104).
There were 42 deaths from lymphohematopoietic cancers (LHC) with 28.6 expected (SMR=147,95% Cl=106-198), 9 observed vs. 4.7 expected deaths for lymphosarcoma (SMR=191,95% CI=87-364), 13 observed vs. 11.5 expected deaths for leukemia (SMR=113,95% CI=60-193), and 15 observed vs. 9.9 expected deaths from cancer of other lymphatic tissue (SMR=152,95% CI=85-250). (...)
Mots-clés Pascal : Butadiène, Exposition professionnelle, Industrie chimique, Mortalité, Carcinogène, Homme, Toxicité, Médecine travail, Tumeur maligne, Etude longitudinale, Epidémiologie
Mots-clés Pascal anglais : Butadiene, Occupational exposure, Chemical industry, Mortality, Carcinogen, Human, Toxicity, Occupational medicine, Malignant tumor, Follow up study, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0027912
Code Inist : 002B04E02. Création : 21/05/1997.