Evaluation of Butadiene and Isopropene Health Risks. International Symposium. Blaine, Washington (USA), 1995/06/27.
The IARC has given the designations of « sufficient evidence » of carcinogenicity of 1,3-butadiene in experimental animals and « limited evidence » of carcinogenicity in humans.
To investigate the carcinogenic effect in humans, a cohort mortality study was conducted among 364 men who were assigned to any of three 1,3-butadiene production units located within several chemical plants in the Kanawha Valley of West Virginia, including 277 men employed in a U.S. Rubber Reserve Plant which operated during World War II.
The butadiene production units included in this study were selected from an index developed by the Union Carbide Corporation which listed for each chemical production unit within their South Charleston and Institute plants all products, by-products and reactants.
Departments included in the study were those where butadiene was a primary product and neither benzene nor ethylene oxide was present.
A total of 185 deaths were observed ; the standardized mortality ratio (SMR) for all causes of death was 91, reflecting lower mortality among the study population than the U.S. population.
The study found a significantly elevated standardized mortality ratio (SMR) for lymphosarcoma and reticulosarcoma based on four observed cases (SMR=577 ; 95% confidence interval (CI)=157-1480), which persisted in an analysis using county referent rates. (...)
Mots-clés Pascal : Butadiène, Exposition professionnelle, Homme, Epidémiologie, Industrie chimique, Mortalité, Toxicité, Carcinogène, Médecine travail
Mots-clés Pascal anglais : Butadiene, Occupational exposure, Human, Epidemiology, Chemical industry, Mortality, Toxicity, Carcinogen, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0027169
Code Inist : 002B04E02. Création : 21/05/1997.