Biological monitoring for mutagenic effects of occupational exposure to butadiene.
Evaluation of Butadiene and Isopropene Health Risks. International Symposium. Blaine, Washington (USA), 1995/06/27.
The use of biological markers in the evaluation of human exposure to hazardous agents has increased rapidly in recent years.
Because 1,3-butadiene is a mutagenic carcinogen, existing occupational levels of exposure may be appropriately evaluated using somatic cell mutation as a biomarker.
Previously, we have described a biomarker study of workers in a butadiene monomer plant (Ward et al., 1994).
We now report results from a second study of the same group of workers, conducted after plant modernization, and present preliminary results from a study of exposures in a styrene butadiene rubber (SBR) plant.
Air levels of butadiene were determined using either charcoal tubes with air pumps or passive badge dosimeters.
The quantity of a butadiene metabolite in the urine was used as a biomarker of exposure and the mutagenic effects of exposure were measured using the autoradiographic hprt mutant lymphocyte assay.
In all three studies, the frequencies of hprt mutants were significantly elevated in workers from the areas of highest exposure when compared to workers from lower exposure areas or non-exposed subjects.
The concentration of the urinary metabolite was significantly increased in high-exposed workers in the first study of monomer plant workers but not in the second.
In the first monomer plant study, historical air concentrations of butadiene were higher in the production units than in the central control unit. (...)
Mots-clés Pascal : Butadiène, Mutagène, Exposition professionnelle, Homme, Surveillance biologique, Médecine travail
Mots-clés Pascal anglais : Butadiene, Mutagen, Occupational exposure, Human, Biological monitoring, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0027130
Code Inist : 002B03N. Création : 21/05/1997.