hprt mutation frequency among workers exposed to 1,3-butadiene in China.
Evaluation of Butadiene and Isopropene Health Risks. International Symposium. Blaine, Washington (USA), 1995/06/27.
Hypoxanthine-guanine phosphoribosyl transferase (hprt) mutation frequency (Mf) was studied in workers at a polybutadiene rubber production facility in Yanshan, China.
Exposed workers included for study were active either as process analysts, who sampled butadiene production process lines and analyzed product by gas chromatography, or as process operators, who did routine process control, minor maintenance and, as needed, major repair operations.
For process analysts at the polymer and dimethyl formamide (DMF) facilities, the median air levels of BD were 1.0 and 3.5 ppm, respectively.
Among process operators, air levels of 1.1 ppm were found during routine activities, while the median air level during pump repair and related operations was 45 ppm (6-h time-weighted average).
Overall, Mf was similar in unexposed (mean Mf=20.2 x 10-6) and butadiene-exposed (mean Mf=21.6 x 10-6) workers (P=0.68).
Mf decreased with cloning efficiency, increased with age, and was moderately greater in women than in men.
After adjustment by multiple regression analysis for mean age, sex, and cloning efficiency, the adjusted mean Mf (Xadj) was 13.6 x 10-6 in unexposed and 18.0 x 10-6 in butadiene-exposed.
This 32% difference was, however, not statistically significant (P=0.13).
Butadiene exposure was associated with a modest, if any, increase in hprt Mf in this population of Chinese workers.
Mots-clés Pascal : Butadiène, Mutagène, Exposition professionnelle, Homme, Chine, Asie, Mutation, Toxicité, Médecine travail, Géne hprt
Mots-clés Pascal anglais : Butadiene, Mutagen, Occupational exposure, Human, China, Asia, Mutation, Toxicity, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0027034
Code Inist : 002B03N. Création : 21/05/1997.