To examine inter-spouse transmission as one of the potential routes of infection for hepatitis C virus (HCV), 121 patients with HCV-related chronic liver disease who tested positive for antibodies to HCV (anti-HCV) and their spouses were studied.
Of these, 21 (17.4%) patients had spouses with anti-HCV.
In 12 couples, the HCV genotype matched (type II : 10 couples, type III : two couples).
The genotype differed in six couples.
One patient was positive for anti-HCV, but negative for HCV-RNA, while the spouse was positive for both.
The remaining two couples were only positive for anti-HCV.
Genetic heterogeneity in the hypervariable region 1 of HCV was analysed in 11 couples with matched genotypes.
In two couples, no mutation was recognized in the putative E2/NSI genes using the heteroduplex method.
The present study provides evidence to verify household transmission of HCV between patients and their spouses.
These results suggest that inter-spouse transmission may be a potential route of transmission of HCV infection.
However, other environmental factors (e.g. the duration of the marriage) cannot be ignored.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Facteur risque, Transmission, Conjoint, Exploration microbiologique, Génotype, Etude statistique, Homme, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Risk factor, Transmission, Spouse, Microbiological investigation, Genotype, Statistical study, Human, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0022685
Code Inist : 002B05C02G. Création : 21/05/1997.